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The United States–Pakistan relations refers to the international, historical, and cultural bilateral relationship between the Islamic Republic of Pakistan and the United States of America. Roughly two months of its establishment after the departure of the subcontinent by Great Britain, the United States established relations with Pakistan on 20 October 1947.

The United States was amongst the first nations to have established relations with Pakistan in late 1940s, but since then, relations have been centred around the United States' extensive economic, scientific, and military assistance to Pakistan. Allying with the U.S. during the Cold war against the USSR, Pakistan was an integral in CENTO and SEATO— both alliances opposed the Soviet Union and Communism. Relations were soured in 1970s with the left-oriented PPP led government which came in power in 1971. However, the closely coordinated military cooperation deepened in 1980s against Soviet expansion in Central Asia. After the disintegration of USSR, and Pakistan's subsequent return to democracy, the relations once again became cold with the U.S. imposing an economic embargo against Pakistan during the most of 1990s. Currently, Pakistan is designated as a Major non-NATO ally of the United States, which is the second-largest supplier of military equipment to Pakistan after China, and largest economic aid contributor as well.

Since 2011, the intensive criticisms and allegations of each other based on their strategies in the War on Terror have hindered relations. Furthermore, as a result of the Lahore incident and the black operation in the country which killed the al-Qaeda leader Osama bin Laden, followed by the Salala incident, relations between two countries were severely damaged, and was also a crucial point in the history of bilateral relations of both countries.